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Ethics declarations Conflict of interest F.C.S declares grants from NIH/NIDDK (P30 DK040561, U24 DK132733, and UE5 DK137285) and consulting fees from Eli Lilly, Novo Nordisk, Amgen, Boehringer Ingelheim, AstraZeneca, AbbVie, Currax, Pfizer, Doximity, MelliCell, Vida Health, Empros Pharma, Apnimed, Clearmind Medicine, and Ilant Health, all outside of the current work

This relationship provides putative mechanisms underlying neurological impairments and identifies specific therapeutic targets that address both the root pathophysiology and its wider systemic effects, providing a pathway to precise treatment for neurological affectations and to appropriately treat the underlying causation