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In conclusion, our findings uncovered a novel physiological role for GH, which is to signal caloric deficiency to the brain, triggering important adaptive responses to conserve energy via activation of AgRP neurons

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The affected enzymes, ERK1/2, along with their downstream targets, including c-Fos, c-Jun, and Egr-1, are believed to play significant roles in cell growth, migration, and angiogenesis, which is the development of new blood vessels

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