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Journal of Urology 2008

In the Central Nervous System GH and IGF-1 both contribute to neural development, nerve myelination, amyloid clearance so important in the development of Alzheimers disease and anti-inflammatory mechanisms within the central nervous system

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The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice