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Despite these advantages, many current HILIC methods still rely on chemical derivatization to achieve adequate sensitivity [48, 59,60,61] or depend entirely on MS/MS specificity while neglecting optimal chromatographic separation, which can lead to severe matrix interferences and ion suppression [41]

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A broader 2020 review by Sikiric and colleagues in Gut and Liver frames the compound's proposed GI activity within Robert's cytoprotection and organoprotection model the longstanding physiological framework describing how the gastric mucosa protects itself against injury