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Mitochondrial membrane debris is commonly found in plaque deposits in the brain, and we hypothesize that the fibrils sequester deuterium-doped lipids, resulting in reduced deuterium burden in the cell and the tissue
But during the life the lens is exposed to multiple sources of oxidative stress, endogenous (altered mitochondrial respiration, respiratory burst of phagocytes, viral infection) and exogenous (UV light, metals, drugs, cigarette smoke), which can lead to production of reactive oxygen species: superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (HO) and others
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Some lyophilization processes create denser powder requiring 5-10 minutes hydration before complete dissolution
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