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However, a significant caloric deficit, especially one this pronounced, often comes at a cost: the loss of precious lean muscle mass

Group A received oral tranexamic acid 250 mg twice daily in combination with a topical modified Kligman regimen (fluocinolone acetonide 0.01% + hydroquinone 4% + tretinoin 0.05%) and the group B received oral glutathione 500 mg with modified Kligman regimen as above for 8 weeks and then twice in a week at night for the next 4 weeks

In brief, animals ( n = 8 per group, per sex) were placed into individual cages at their standard temperature and photoperiod and allowed to acclimate for at least 72 h prior to the experiment, and data were collected over a 24 h period

4 These episodes start abruptly with a scream or panicked cry, and are followed by feelings of terror, along with physical fear responses