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Phase 2 safety profile is consistent with the GLP-1 receptor agonist class, dominated by dose-dependent gastrointestinal adverse events that concentrate in the first one to two weeks of each escalation step

Harsh but true

The combination of phentermine, a psychostimulant, and topiramate, a carbonic anhydrase inhibitor, has been associated with increased heart rate (Alfaris 2015)

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