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The FDA has issued communications addressing risks associated with some compounded GLP-1 products, and the regulatory landscape for compounded medications continues to evolve

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investigated infertile PCOS patients with obesity randomly assigned to metformin 1000 mg BID or to metformin 1000 mg BID combined with low-dose liraglutide 1.2 mg/day for 12 week, and demonstrated that weight, BMI, and WC decreased with both treatments, without significant difference between the two arms [59]

GLP-1 agonists usage in patients with MASLD is associated with reduced risk of major cardiovascular events, clinically significant portal hypertension, and all-cause mortality