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It reduces hepatic inflammation and oxidative stress by modulating the SIRT1/Nrf2/NF-B axis, thereby restoring liver function

Medical history: A review of symptoms related to oxidative stress and immune system function

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[12] Threshold intake levels for adverse effects [edit] Adverse health and social effects associated with kava consumptionsuch as skin rashes, increased body mass index (BMI), elevated gamma-glutamyl transferase (GGT) enzyme levels, and higher lymphocyte countsmay begin to appear at intake levels of approximately 240 to 440 grams of kava powder per week, corresponding to 3,500 to 6,440 mg of kavalactones per day