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Matt Kaeberlein (UW Medicine, Optispan) observed: Expecting a single drug to meaningfully alter the course of Alzheimers once cognitive decline is underway is an extraordinarily high bar. The EVOKE population already had MCI or mild dementiameaning pathological cascades were well-established

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None of them have gone through what would be considered adequate clinical trials, but nonetheless many people are taking these

While still less common, it offers the convenience of an oral route, making it more accessible for some patients