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Sirtuins are a family of NAD-dependent deacetylases that remove acetyl groups from proteins, influencing gene expression, DNA repair, metabolism, and stress responses
if neurological involvement is present, maintenance is every two months Oral therapy is generally not appropriate where absorption is impaired (e.g., pernicious anaemia), as adequate levels cannot be reliably achieved Because B12 is water-soluble and any excess beyond hepatic storage capacity is excreted in the urine, it has a low toxicity profile
The combination of Milk Thistle and Vitamin C with glutathione is very effective
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