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If your BMI is 30 or above, or 27+ with health issues like high blood pressure or insulin resistance, you may be eligible
The most notable of these potential complications would be insulin resistance and severe cardiovascular complications [R, R]
Mechanism involves NO system modulation (homeostatic regulationupregulating when deficient, moderating when excessive), VEGF/VEGFR2 upregulation for angiogenesis, FAK-paxillin pathway activation for cell migration (40% increase per Chang et al.), and EGR-1 transcription factor upregulation for growth factor sensitivity
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