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The SUMMIT trial took this further with tirzepatide, showing a 38% reduction in the composite of cardiovascular death or worsening heart failure (HR 0.62) in patients with HFpEF and obesity, along with a clinically meaningful 6.9-point improvement in KCCQ scores
Both preclinical and clinical studies have demonstrated that GLP-1s modulate the gut microbiota composition by delaying gastric emptying and altering luminal glucose (12)
Tips for maximizing results with Shed tirzepatide Getting the most from your Shed tirzepatide program requires more than just taking the medication
This lack of lifestyle integration not only blunts weight loss (since diet/exercise contribute significantly), but also magnifies attrition patients who arent seeing lifestyle progress or feel unsupported are more likely to give up on the medication when challenges arise
