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It works by simultaneously activating the glucose-dependent insulinotropic polypeptide receptor (GIP-R) and glucagon-like peptide-1 receptor (GLP-1R), which results in increased insulin release, decreased glucagon secretion, reduced hunger, delayed gastric emptying, and significant weight loss

Phagocytosed photoreceptor outer segments are highly enriched in polyunsaturated fatty acids and are the major source of intracellular ROS generation in RPE 3,4

Injections bypass the gastrointestinal tract and are the standard treatment for pernicious anaemia and severe deficiency in the UK

Given the FoxO1 ablation induced -cell dedifferentiation and caused hyperglycemia under physiologic stress 22 , we determined whether LOsG/ROS stresses decrease FoxO1 expression and thus induce -cell dedifferentiation