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A 2019 randomized controlled trial of lipotropic injections (methionine, inositol, choline, B12) versus saline placebo in 120 participants on ad libitum diets found 0.8 kg (1.76 pounds) difference at 12 weeks, not statistically significant (p=0.18) (Karbalay-Doust et al., Journal of Research in Medical Sciences , 2019)
For pain management specifically, it excels at promoting tendon and ligament healing, muscle repair and recovery, reduced pain perception, improved joint function, and accelerated healing of soft tissue injuries
The benefit is mostly the floor coming up rather than the ceiling coming down: the trough rises by roughly half while the peak moves comparatively little, so the curve is flatter and the swing after each injection is smaller
