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Collectively, these data indicate that GSH depletion selectively promotes oxidation and degradation of FASN in hepatocytes
Sulforaphane is a potent Nrf2 agonist, which is found in high amounts in broccoli
Conditional depletion of methyl-CpG-binding protein 2 in astrocytes depresses the hypercapnic ventilatory response in mice
Critical challenges include achieving effective bloodbrain barrier penetration, minimizing neurotoxicity and off-target ferroptosis, addressing tumor heterogeneity in iron metabolism, and understanding compensatory pathways that regulate iron homeostasis
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