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Preclinical data suggests AOD9604 shifts the metabolic balance toward burning fatty acids for energy rather than storing them, with effects observed particularly in visceral adipose tissue

Oral supplementation has shown effectiveness but may not match the efficacy of IM in certain scenarios

This inhibition preserves cellular NAD+ levels by reducing their consumption, simultaneously increasing GLUT4 transporter expression and activating sirtuin 1, known as the "longevity gene." The compound exhibits high membrane permeability and selectivity without affecting related methyltransferases or NAD+ salvage pathway enzymes, creating targeted metabolic effects while maintaining cellular safety

In animal studies, inhibiting NNMT has been associated with altered energy handling in fat cells and with preserved SAM and NAD availability