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These data require further studies to be confirmed, but establish incretins as a key therapy for future clinical practice

While some research suggests that B12 levels may influence fat metabolism and body composition, the relationship isnt fully understood

The most important serious side effects include acute pancreatitis (severe persistent abdominal pain radiating to the back, though clinical trials found similar pancreatitis rates to comparators), severe dehydration from persistent vomiting or diarrhea (signs include dizziness, decreased urination, extreme thirst), gallbladder disease including cholecystitis or cholelithiasis (right upper quadrant pain, fever, jaundice), severe allergic reactions (difficulty breathing, swelling of face or throat), and severe hypoglycemia when combined with insulin or sulfonylureas (confusion, loss of consciousness, seizures)

This substantial caloric deficit, while necessary for weight loss, can result in decreased energy availability for daily activities