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The hypothalamic-pituitary-ovarian axis, which governs reproductive function, is sensitive to energy availability

PLoS One 8 , e57758 (2013)

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GLP1/E therapy also elicited specific changes in the hypothalamic proteomic profile in PNA mice, upregulating proteins involved in the metabolism of non-coding RNA, signaling of nuclear receptor and estrogen-dependent gene expression and downregulating pathways involved in apoptosis, signaling by insulin receptor and cellular responses to starvation