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Contact your GP or healthcare professional (for example, your GP, pharmacist or diabetes specialist) if you experience: Palpitations that are persistent, severe, or accompanied by chest discomfort Dizziness or lightheadedness , particularly if associated with near-fainting episodes Chest pain or pressure , especially during physical activity Shortness of breath that is new or worsening, particularly at rest Unusual fatigue or reduced exercise tolerance A resting heart rate consistently above 100 beats per minute when measured at rest For urgent but non-emergency concerns, you can contact NHS 111 for advice

A blockbuster GLP-1 faces fresh scrutiny over rare optic nerve risk

PraderWilli syndrome and the hypothalamus