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The STEP trials (20212023) demonstrated that semaglutide produces 1522% body-weight loss over 68 weeks when combined with lifestyle changes, compared to 23% weight loss with placebo
When they do occur, they are often linked to the body adjusting to weight loss, metabolic changes, or the overall treatment journey
Regular follow-ups occur monthly during initial treatment phases, then every 2-3 months once stable
Common adverse effects are predominantly gastrointestinal and typically emerge during dose escalation: Nausea (affecting 2050% of users initially) Vomiting and diarrhoea Constipation Abdominal pain and bloating Reduced appetite (therapeutic effect but may be excessive) Fatigue and headache Injection site reactions (redness, swelling or itching) These effects usually diminish over several weeks as the body adjusts
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