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Ozempic should be initiated at a low dose to minimize gastrointestinal symptoms

Data analysis RNA-seq reads were aligned to the human genome (hg37) using the STAR aligner, and the number of reads mapping to genes annotated in Gencode build 37 (v22) was calculated using HTseq

Definition: damage to the myelin sheath of the white matter in the CNS caused by a sudden rise in serum osmolality Central pontine myelinolysis Most common type Affects the central region of the pons Extrapontine myelinolysis: can affect the cerebellum, lateral geniculate body, thalamus, putamen, cortical, and/or subcortical white matter Causes Iatrogenic: rapid correction of chronic hyponatremia High-risk factors for ODS: alcohol use disorder, malnutrition, liver disease, hypokalemia, initial sodium concentration 105 mEq/L [2] Rapid changes in other osmotically active solutes (e.g., glucose) Acute severe hypernatremia Clinical features [30] [31] Symptoms first develop several days after the correction of hyponatremia