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In 2021, the New England Journal of Medicine published the STEP 1 trial results: adults with obesity receiving semaglutide 2.4 mg/week lost an average of 14.9% of body weight over 68 weeks, compared to 2.4% in the placebo group (Wilding et al., NEJM, 2021)

The medication works by mimicking the action of the naturally occurring hormone GLP-1, which stimulates insulin secretion in response to food intake, suppresses glucagon release, and slows gastric emptying

And the quintuple agonist profile is incredibly elegant mechanistically

STEP HFpEF is the first randomized clinical trial to show that intentional weight loss (via semaglutide) results in significant improvement in clinical status for patients with heart failure and preserved ejection fraction