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The intracellular signaling cascades activated during dosing PI3K/Akt/mTOR for synthesis, FoxO suppression for anti-catabolism do not terminate immediately when plasma LR3 clears (Yoshida & Delafontaine, 2020)

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Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic beta-cells