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Polar residues are replaced by alanines and hydrophobic residues by Ala/Ser/Thr

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Immunohistochemistry for cytotoxic molecules (such as granulysin, perforin, and granzyme B), CD4 and Treg can help differentiate SJS/TEN from EMM [69]

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NMDA Receptor Modulation In brain research models, DSIPs effects appear to be at least partly mediated via NMDA receptors a glutamatergic ionotropic receptor family central to synaptic plasticity, learning and memory, and excitatory neurotransmission

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JAMA Internal Medicine, 184 (9), 1056-1064

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