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Effect of semaglutide treatment on a proteomic signature of CVD risk A 27-protein score has previously been described that predicts secondary CVD risk over 4 years, based on large multicohort data and using the same SomaScan technology used in our study 22 (Extended Data Table 1)

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Notably, the study observed changes in acyl-carnitine levels after 8 weeks of treatment, indicating potential metabolic responses to therapy

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