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During the initial colonization phase, the mucus layer becomes more dynamic, turning over faster than usual
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While traditional models often address hyperandrogenism and IR as primary, parallel drivers of PCOS pathology, they frequently fail to account for the rising evidence of systemic low-grade inflammation and immune dysregulation in the syndrome, particularly the pervasive role of the gut-metabolic axis [2, 16, 17]
The results indicate a synergistic effect between the cyclodextrin and the other excipients in the co-formulation, widening the preferred range of molar substitution (Average MS 0.62-0.92)
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