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Research also suggests it plays a regulatory role in the hypothalamicpituitaryadrenal (HPA) axis, helping to support balanced cortisol rhythms and a more adaptive stress response

Granata R et al

(7) These MC4R-sensitive circuits, potentially located in regions such as the paraventricular nucleus of the hypothalamus, might release endogenous oxytocin in response to Melanotan 2, possibly recalibrating imbalanced neurochemical activity thought to underlie key aspects of social impairment