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Efficacy and safety of tirzepatide monotherapy in type 2 diabetes (SURPASS-1)
Practitioners should also consider the products safety profile and regulatory status when advising patients
Previous preclinical work has also demonstrated LS involvement in GLP-1R-mediated reward processing for both alcohol (21, 24) and cocaine-related behaviors (52, 76), as well as regulation of alcohol-induced dopamine release in the NAc (24)
Molecular recognition The activated GLP-2R structure shows that GLP-2 is stably anchored in its position through an extensive network of interactions that involves TMs 1, 2, 3, 5 and 7, and ECLs 1, 2 and 3 (Fig
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