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Common Mild Side Effects Short-term redness or slight irritation at the injection site Light water retention, especially during the initial weeks Increased appetite Mild headaches (rare and usually transient) Temporary fatigue or lightheadedness immediately after injection Who Should Avoid This Therapy People with an active cancer diagnosis or history of cancer, as GH secretagogues increase cellular replication rates Pregnant or breastfeeding individuals should avoid this therapy due to insufficient safety data on its effects during these stages

Gray-market retailers currently selling ipamorelin are circumventing these regulated and credentialled pathways and could potentially introduce the risk of impurities if substandard processes are used

Moreover, GPCR signaling has been shown to transactivate different metalloproteinases (MMPs) (Lin, 2025), and MMP-8 has been found critical in occludin cleavage upon meningococcal infection in endothelial cells (Schubert-Unkmeir et al., 2010)