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Ipamorelin stimulates a strong GH pulse while avoiding increases in ACTH, cortisol, or prolactinmaking it a safer alternative to earlier peptides. Smith et al., Journal of Clinical Endocrinology & Metabolism In essence, Ipamorelin acts as a selective growth hormone enhancer , offering the anabolic and regenerative benefits of GH elevation without the hormonal chaos seen with many other compounds
Bland JS et al
It included 40 kids, ages 4 to 16, in a carefully controlled test where some got magnesium, and others got a harmless pill with no effect
In published in-vitro and animal research, GHRH analogs such as tesamorelin and Modified GRF (1-29) have been investigated for their ability to stimulate pituitary somatotrophs, while ipamorelin has been studied as a selective GH secretagogue reported to have minimal effect on cortisol or prolactin in animal models
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