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In addition to these widely used AOMs, Exenatide, one of the earliest GLP-1 RAs approved by the FDA and EMA for T2DM management, is not indicated for weight management but remains clinically relevant, particularly in older adults with comorbid obesity and T2DM, given its long-term clinical experience and established tolerability profile [26,27,28]

If appetite control feels minimal or weight loss stalls completely, extending time at 0.25mg before advancing may not help

Less severe but still problematic gastrointestinal reactions warrant dose holds and systematic side effect management

Emerging prospects of macro-and microalgae as prebiotic