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Studies have shown that semaglutide therapy leads to reductions in HOMA-IR scores , though it is important to note that these improvements are largely mediated by weight loss

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146,147 In a controlled trial, subjects who participated in a program teaching mindful eating and prolonged chewing lost more weight, engaged in less emotional- and cue-stimulated eating, and reported fewer cravings compared with matched counterparts placed on a waiting list

This reservoir extends the duration of action beyond what the blood concentration alone would suggest