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These chronic attributes are generally associated with selective degeneration of dopaminergic neurons, corollary de-pigmentation of substantia nigra pars compacta (SNpc) and concomitant accumulation of -synuclein in insoluble inclusions called Lewy bodies 2,3
In all three diseases, evidence of this vicious cycle has been observed ( 2.2.2 Dysfunction of innate immune cells in neurodegenerative disease In homeostasis, microglia are responsible for surveying the environment and responding to injury or infection
PMID 20561558
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