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Factors like temperature and physical activity can alter this
In contrast, drugs with a narrow therapeutic window can be particularly vulnerable
observed that in the TRE group, the decline in the bone formation marker P1NP was significantly attenuated (-0.22 vs -4.07 ng/mL), indicating potential bone-protective effects
12,13 Modifications to prolong the half-life of GLP-1 RAs include sequence substitutions conferring resistance to DPP-4, along with acylation (liraglutide and semaglutide), covalent bonding to modified Ig fragment crystallisable domain (dulaglutide), or covalent bonding to albumin
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