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In hepatocellular carcinoma (HCC) cells, post-translational activation of cystathionine -synthase (CBS) under TNF-induced oxidative stress increases TSS activity through a proteolytically cleaved and highly active form of CBS, increasing cystathionine and GSH production (102), which in turn promotes tumor progression and inhibits ferroptosis
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Licensed recombinant human growth hormone (somatropin) is available on the NHS for confirmed GH deficiency in both children and adults, subject to NICE criteria
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