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Clinical data prioritize monotherapy optimization: the SURMOUNT and SURPASS trials demonstrated tirzepatide monotherapy reduced weight by up to 20% and semaglutide monotherapy by up to 18% at maximum approved doses
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The Shot: Patients often report feeling the appetite-suppressing effects of the injection relatively quickly, sometimes within the first week or two of the starting dose (0.25 mg)
understanding the causes makes that difference predictable and manageable
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