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The shots usually don't hurt, but some people have a slight stinging sensation

When to decrease dose Consider decreasing if: Persistent side effects that don't resolve Excellent results achieved and maintenance desired Budget constraints require conservation Stacking and wanting to optimize ratios Many researchers find they can reduce dose during maintenance phases after achieving initial goals during more intensive loading phases

Rather than supplying additional precursors, it limits NAD+ depletion by inhibiting NNMT, allowing exploration of upstream metabolic control