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Our study showed that HepG2 cells, which primarily rely on extracellular cystine as a source of cysteine 20 , responded to cystine deprivation by reducing anabolic signaling including attenuation of mTORC1 pathway and activation of the ISR (Fig
It can even lead to neurological problems such as amyotrophic lateral sclerosis (ALS), Parkinsons disease, or Alzheimers disease
It also activates the NO system and demonstrates broad cytoprotective properties
Liu C, Wu J, Zou MH
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