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Although hypersegmented neutrophils (ie, neutrophils with five or more nuclear lobes) are most often associated with megaloblastic anemia (eg, folic acid or vitamin B12 deficiency, including pernicious anemia), they may also be seen in myelodysplastic syndromes, in patients receiving chemotherapy, or in long-term chronic infections
Glutamate homeostasis refers to the homeostatic regulation of non-synaptic primarily glial extracellular glutamate by cystineglutamate exchange and glutamate uptake, and the impact of this glutamate on pre- and postsynaptic metabotropic glutamate receptors in terms of regulating synaptic efficiency and plasticity
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