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Variants in FTO , the fat-mass and obesity-associated gene, along with GLP1R (the GLP-1 receptor gene that every GLP-1 compound targets), MC4R (a melanocortin receptor tied to satiety and energy balance), and TCF7L2 (a transcription factor linked to glucose homeostasis) describe the metabolic terrain a clinician is prescribing into

From the above evidence, it is clear that the best approach for the management of patients on GLP-1RAs still needs further investigation

While nausea can be uncomfortable, fewer than 10% of people in clinical trials stopped their medication because of gastrointestinal issues

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