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This study aims to review the latest research progress in the application of GLP-1RAs in the management of sarcopenia, analyze its key molecular pathways, and explore its role in insulin resistance, mitochondrial function, inflammation, protein metabolism balance, autophagy, and the activation of related signaling pathways

Case presentation SL was a 44 year old Caucasian male with a past medical history of severe morbid obesity (BMI 99), heart failure with preserved ejection fraction, oxygen-dependent obesity hypoventilation syndrome (OHS), chronic non-healing leg wounds, anemia, uncontrolled hypertension on 2 anti-hypertensive agents, limited mobility, and major depressive disorder who presented to an academic medical center for treatment of acute on chronic diastolic heart failure due to progressive dyspnea

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