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Single-cell RNA sequencing analysis identifies enhanced expression of senescence-associated secretory phenotype genes, elevated p16 protein levels, and increased -galactosidase-positive cells in keloid tissue compared to normal skin
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ASK1, also known as MAP3K5, activates the downstream p38-JNK1/2 signalling pathway, thereby promoting inhibition of lipid and glucose metabolism 34,35,36 and driving a strong inflammatory response 37
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