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Numerous studies have investigated the expression patterns of endogenous GLP-1 and GLP-1R in the central nervous system (CNS) and the peripheral nervous system, with a consensus that these are expressed on neurons and found in most areas of the brain and gutbrain axis 2

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Because the published Phase 2 pharmacology characterizes it as having comparable potency at all three receptors rather than being a single-receptor compound with weak off-target activity