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ER stress is activated by lipotoxicity and leads to the activation of the unfolded protein response (UPR) that causes hepatocyte apoptosis and inflammation
Reactive Oxygen Species (ROS) Attenuation Studies indicate that MT-1mediated cAMP elevation enhances antioxidant defense mechanisms in melanocytes, reducing UV-induced ROS accumulation and oxidative DNA damage through upregulation of superoxide dismutase and catalase activity (Abdel-Malek et al., Endocrine Reviews, 2010)
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