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10.1016/j.oraloncology.2012.02.020 Oral Oncol

Your digestive system typically adjusts within a few months, though some changes are permanent: Bile flows continuously rather than in concentrated bursts Fat digestion may be less efficient initially Some people experience digestive changes like looser stools Research shows that following gallbladder removal, many people experience modest weight gain

The health cost of delaying treatment (continued obesity-related complications, reduced quality of life) is harder to quantify but clinically significant

This is particularly important given that melatonin can influence other hormonal systems