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The inclusion criteria were: Original research articles, Studies investigating ROS or free radical-related mechanisms in ovarian cancer, Studies that included in vitro experiments, whether alone or in combination with in vivo data, and Studies in which ROS (or ROS-generating/redox-regulatory pathways) were experimentally linked to pro-tumorigenic outcomes, including enhanced proliferation/survival, angiogenic signaling, EMT/migration/invasion, or therapeutic resistance, and/or in which ROS suppression (e.g., antioxidants, inhibition of ROS sources, or genetic perturbation of redox regulators) attenuated these malignant phenotypes
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Severe vitamin B 12 deficiency in a mouse model showed dramatic alterations in the level of DNA methylation in the brain, which might lead to neurologic impairments (103)
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