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The activation of hypothalamic neurons, suppression of food intake, and weight loss induced by liraglutide were attenuated in mice with impaired transcellular transport in tanycytes or in mice with a tanycyte-specific GLP-1 receptor knockdown [7]

The low and medium monthly maintenance regimens planned for Phase 3 showed strong efficacy, achieving 10% and 12.3% placebo-adjusted weight loss in Arms 1 and 3, respectively

The review quantified weight regain after stopping weight management medications and estimated an average regain of about 0.9 pounds per month, with weight and cardiometabolic improvements projected to drift back toward baseline within roughly 1 to 2 years after stopping

Circadian rhythms and tumor growth