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In this real-world setting, patients who were treated with semaglutide 2.4 mg and tirzepatide had a mean weight loss of 14.1% and 16.5% at 1 year, respectively, which represents a clinically meaningful weight loss with both therapies when used in patients with overweight or obesity and without T2DM [20]

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Materials and methods Study design, participants, and procedures This was a randomized, double-blind, placebo-controlled study with a double-dummy, and crossover design