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If your refrigerator has cold spots near the freezer compartment, or if you accidentally placed a vial in the freezer and then thawed it, the damage from a single freeze-thaw event can reduce potency by 30-50% or more
This information should be interpreted with a qualified provider to potentially inform which formulation or dose tier may fit your metabolic profile, reducing costly trial-and-error cycles
OTC folinic acid is sold as a dietary supplement with lower doses (usually 800 mcg5 mg), while prescription leucovorin is typically supplied in 5 mg or higher tablets Washington Post
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